Abstract
A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Blood Proteins / metabolism*
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Cell Line
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Cell Membrane / metabolism
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Cell Polarity
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Cytoskeletal Proteins / metabolism*
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Cytoskeleton / metabolism*
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Humans
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Membrane Proteins / metabolism*
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Microfilament Proteins / metabolism*
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Models, Biological
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Multigene Family
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Neurofibromin 2 / metabolism*
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Phosphoproteins / metabolism*
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Phylogeny
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Protein Structure, Tertiary
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Signal Transduction / physiology
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Tumor Suppressor Proteins / metabolism
Substances
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Blood Proteins
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Cytoskeletal Proteins
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Membrane Proteins
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Microfilament Proteins
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Neurofibromin 2
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Phosphoproteins
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Tumor Suppressor Proteins
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ezrin
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moesin
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radixin