Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)

Delshanee Kotandeniya; Brian Ganley; Kent S Gates

doi:10.1016/s0960-894x(02)00468-7

Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2325-9. doi: 10.1016/s0960-894x(02)00468-7.

Authors

Delshanee Kotandeniya¹, Brian Ganley, Kent S Gates

Affiliation

¹ Department of Chemistry, University of Missouri-Columbia, 65211, USA.

PMID: 12161126
DOI: 10.1016/s0960-894x(02)00468-7

Abstract

Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tumors. In this work, base excision repair enzymes were used to provide evidence that tirapazamine causes significant amounts of damage to both purine and pyrimidine residues in double-stranded DNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology*
DNA / metabolism
DNA Damage / drug effects*
DNA Ligases / metabolism
Oxidation-Reduction
Purines / analysis
Pyrimidines / analysis
Restriction Mapping
Substrate Specificity
Tirapazamine
Triazines / pharmacology*

Substances

Antineoplastic Agents
Purines
Pyrimidines
Triazines
Tirapazamine
DNA
DNA Ligases