Abstract
Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.
MeSH terms
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Amino Acid Sequence
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Casein Kinases
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Cytoskeletal Proteins / metabolism
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Molecular Sequence Data
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Phosphorylation
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Protein Kinases / chemistry
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Protein Kinases / metabolism*
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Proto-Oncogene Proteins / metabolism*
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Signal Transduction
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Trans-Activators / metabolism
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Wnt Proteins
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Zebrafish Proteins*
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beta Catenin
Substances
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Cytoskeletal Proteins
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Proto-Oncogene Proteins
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Trans-Activators
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Wnt Proteins
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Zebrafish Proteins
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beta Catenin
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Protein Kinases
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Casein Kinases