Abstract
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Pressure / drug effects
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Brain / pathology
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Brain Ischemia / drug therapy*
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Brain Ischemia / pathology
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Cyclic GMP / physiology
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Dose-Response Relationship, Drug
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Guanylate Cyclase / metabolism
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In Vitro Techniques
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Infarction, Middle Cerebral Artery / drug therapy
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Infarction, Middle Cerebral Artery / pathology
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Muscle Relaxation
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Muscle, Smooth, Vascular / drug effects
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / pharmacology*
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Nitrates / chemical synthesis*
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Nitrates / pharmacology*
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Nitroglycerin / pharmacology
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Propane / analogs & derivatives*
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Propane / pharmacology
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Rats
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Vasodilator Agents / pharmacology
Substances
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GT 715
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Neuroprotective Agents
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Nitrates
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Vasodilator Agents
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Guanylate Cyclase
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Nitroglycerin
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Cyclic GMP
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Propane