Abstract
Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents / metabolism
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Antidepressive Agents / pharmacology*
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Antidepressive Agents, Tricyclic / metabolism
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Antidepressive Agents, Tricyclic / pharmacology
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Desipramine / metabolism
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Desipramine / pharmacology
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Excitatory Amino Acid Antagonists / metabolism
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Excitatory Amino Acid Antagonists / pharmacology*
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Humans
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Learning / drug effects*
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Learning / physiology
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Male
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Olfactory Bulb / surgery*
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Pyridines / metabolism
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Pyridines / pharmacology*
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Rats
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Rats, Wistar
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Receptors, Metabotropic Glutamate / metabolism
Substances
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Antidepressive Agents
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Antidepressive Agents, Tricyclic
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Excitatory Amino Acid Antagonists
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Pyridines
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate
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6-methyl-2-(phenylethynyl)pyridine
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Desipramine