Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

Angew Chem Int Ed Engl. 2002 Mar 15;41(6):1053-7. doi: 10.1002/1521-3773(20020315)41:6<1053::aid-anie1053>3.0.co;2-4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcholinesterase / chemistry*
  • Animals
  • Binding Sites
  • Cholinesterase Inhibitors / chemical synthesis*
  • Cholinesterase Inhibitors / pharmacology
  • Combinatorial Chemistry Techniques / methods*
  • Drug Design
  • Kinetics
  • Mice
  • Torpedo

Substances

  • Cholinesterase Inhibitors
  • Acetylcholinesterase