Abstract
Termination of translation in eukaryotes has focused recently on functional anatomy of polypeptide chain release factor, eRF1, by using a variety of different approaches. The tight correlation between the domain structure and different functions of eRF1 has been revealed. Independently, the role of prokaryotic RF1/2 in GTPase activity of RF3 has been deciphered, as well as RF3 function itself.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Codon, Terminator
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GTP Phosphohydrolases / metabolism
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Humans
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Models, Genetic
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Models, Molecular
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Molecular Sequence Data
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Peptide Termination Factors / chemistry
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Peptide Termination Factors / genetics
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Peptide Termination Factors / metabolism*
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Protein Biosynthesis*
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Protein Conformation
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RNA, Messenger / metabolism*
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RNA, Ribosomal / metabolism*
Substances
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Codon, Terminator
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ETF1 protein, human
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Peptide Termination Factors
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RNA, Messenger
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RNA, Ribosomal
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GTP Phosphohydrolases