AMP-activated protein kinase, super metabolic regulator

B E Kemp; D Stapleton; D J Campbell; Z-P Chen; S Murthy; M Walter; A Gupta; J J Adams; F Katsis; B van Denderen; I G Jennings; T Iseli; B J Michell; L A Witters

doi:10.1042/bst0310162

AMP-activated protein kinase, super metabolic regulator

Biochem Soc Trans. 2003 Feb;31(Pt 1):162-8. doi: 10.1042/bst0310162.

Authors

B E Kemp¹, D Stapleton, D J Campbell, Z-P Chen, S Murthy, M Walter, A Gupta, J J Adams, F Katsis, B van Denderen, I G Jennings, T Iseli, B J Michell, L A Witters

Affiliation

¹ St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia. kemp@ariel.unimelb.edu.au

PMID: 12546677
DOI: 10.1042/bst0310162

Abstract

The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.

Publication types

Review

MeSH terms

AMP-Activated Protein Kinases
Animals
Diabetes Mellitus / genetics
Gene Expression Regulation
Glucose / metabolism
Glycolysis
Humans
Lipids
Models, Biological
Models, Molecular
Multienzyme Complexes / genetics
Multienzyme Complexes / metabolism
Multienzyme Complexes / physiology*
Mutation
Obesity / genetics
Phosphorylation
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Protein Serine-Threonine Kinases / physiology*
Protein Structure, Tertiary

Substances

Lipids
Multienzyme Complexes
Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Glucose