Abstract
L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated.
Copyright 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:95-97, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10069
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetaminophen / antagonists & inhibitors
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Acetaminophen / toxicity
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Acetylcysteine / pharmacology
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Analgesics, Non-Narcotic / antagonists & inhibitors
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Analgesics, Non-Narcotic / toxicity
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Animals
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Chemical and Drug Induced Liver Injury / prevention & control*
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Cysteine / analogs & derivatives*
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Cysteine / pharmacology*
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Free Radical Scavengers / pharmacology
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Glutathione / analogs & derivatives*
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Glutathione / metabolism
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Glutathione / pharmacology*
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Mice
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Prodrugs / pharmacology*
Substances
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Analgesics, Non-Narcotic
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Free Radical Scavengers
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Prodrugs
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Acetaminophen
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cysteine-glutathione disulfide
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Glutathione
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Cysteine
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Acetylcysteine