Abstract
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis
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Calcium / metabolism
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Cell Movement
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GTP-Binding Proteins / metabolism
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Humans
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Ligands
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Lipid Metabolism*
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Lysophospholipids*
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Models, Biological
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Plants / genetics
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Plants / metabolism
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Receptors, Cell Surface / metabolism
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Receptors, G-Protein-Coupled*
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Receptors, Lysophospholipid
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Signal Transduction*
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Sphingolipids / metabolism
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Sphingosine / analogs & derivatives*
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Sphingosine / genetics
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Sphingosine / metabolism
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Sphingosine / physiology*
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Transcriptional Activation
Substances
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Ligands
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Lysophospholipids
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled
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Receptors, Lysophospholipid
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Sphingolipids
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sphingosine 1-phosphate
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GTP-Binding Proteins
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Sphingosine
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Calcium