Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse

Neurosci Lett. 2003 Jul 17;345(2):73-6. doi: 10.1016/s0304-3940(03)00305-7.

Abstract

We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Biogenic Monoamines / metabolism*
  • Bupropion / pharmacology
  • Extracellular Space / drug effects
  • Extracellular Space / metabolism
  • Fluoxetine / pharmacology
  • Immobilization
  • Mice
  • Mice, Inbred Strains
  • Neurokinin-1 Receptor Antagonists*
  • Piperidines / pharmacology*
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / metabolism
  • Swimming*
  • Tetrazoles / pharmacology*
  • Time Factors

Substances

  • Antidepressive Agents
  • Biogenic Monoamines
  • Neurokinin-1 Receptor Antagonists
  • Piperidines
  • Tetrazoles
  • Fluoxetine
  • Bupropion
  • vofopitant