Abstract
Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue demonstrates reduced body weight, fat mass, and appetite in CB1-/- mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.
Publication types
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Comment
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adipose Tissue / anatomy & histology
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Adipose Tissue / physiology*
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Animals
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Appetite
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Cannabinoid Receptor Modulators
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Cannabinoids / metabolism*
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Endocannabinoids
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Fatty Acids, Unsaturated / physiology*
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Humans
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Ligands
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Lipolysis
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Mice
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Mice, Knockout
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Models, Biological
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Obesity / drug therapy
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Receptors, Cannabinoid
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Receptors, Drug / genetics
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Receptors, Drug / metabolism
Substances
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Cannabinoid Receptor Modulators
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Cannabinoids
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Endocannabinoids
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Fatty Acids, Unsaturated
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Ligands
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Receptors, Cannabinoid
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Receptors, Drug