PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses

G Lambrecht; T Friebe; U Grimm; U Windscheif; E Bungardt; C Hildebrandt; H G Bäumert; G Spatz-Kümbel; E Mutschler

doi:10.1016/0014-2999(92)90877-7

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses

Eur J Pharmacol. 1992 Jul 7;217(2-3):217-9. doi: 10.1016/0014-2999(92)90877-7.

Authors

G Lambrecht¹, T Friebe, U Grimm, U Windscheif, E Bungardt, C Hildebrandt, H G Bäumert, G Spatz-Kümbel, E Mutschler

Affiliation

¹ Department of Pharmacology, University of Frankfurt, Germany.

PMID: 1330591
DOI: 10.1016/0014-2999(92)90877-7

Abstract

We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Electric Stimulation
Male
Prazosin / pharmacology
Purinergic Antagonists*
Pyridoxal Phosphate / analogs & derivatives*
Pyridoxal Phosphate / pharmacology
Rabbits
Synaptic Transmission / drug effects*
Vas Deferens / drug effects
Vas Deferens / innervation

Substances

Purinergic Antagonists
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
Pyridoxal Phosphate
Adenosine Triphosphate
Prazosin