Abstract
The increasing understanding of T-cell activation is paralleled by the recognition of a growing range of 'experiments of nature' that cause T-cell activation deficiencies. Analysis of these deficiencies is, in turn, contributing to the understanding of T-cell function in vivo. Here, José Regueiro, Antonio Arnaiz-Villena and colleagues review current knowledge of structural and functional T-cell defects and the implications of these for T-cell biology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Deaminase / deficiency
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Antigen-Presenting Cells / immunology
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Antigens, CD / physiology
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Cell Adhesion
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Child
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Humans
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / immunology*
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Immunologic Deficiency Syndromes / pathology
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Lymphocyte Activation* / drug effects
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Models, Biological
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Purine-Nucleoside Phosphorylase / deficiency
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Receptors, Antigen, T-Cell / immunology
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Signal Transduction
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T-Lymphocyte Subsets / drug effects
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T-Lymphocyte Subsets / immunology*
Substances
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Antigens, CD
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Receptors, Antigen, T-Cell
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Purine-Nucleoside Phosphorylase
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Adenosine Deaminase