Suppressors of cytokine signaling and immunity

Masato Kubo; Toshikatsu Hanada; Akihiko Yoshimura

doi:10.1038/ni1012

Suppressors of cytokine signaling and immunity

Nat Immunol. 2003 Dec;4(12):1169-76. doi: 10.1038/ni1012.

Authors

Masato Kubo¹, Toshikatsu Hanada, Akihiko Yoshimura

Affiliation

¹ Department of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda 278-0022, Japan.

PMID: 14639467
DOI: 10.1038/ni1012

Abstract

The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

Publication types

Review

MeSH terms

Animals
Carrier Proteins / immunology
Cytokines / immunology*
Humans
Immunity, Innate / physiology*
Intracellular Signaling Peptides and Proteins*
Proteins / immunology
Repressor Proteins / immunology*
Signal Transduction / immunology*
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins
Transcription Factors*

Substances

Carrier Proteins
Cytokines
Intracellular Signaling Peptides and Proteins
Proteins
Repressor Proteins
SOCS1 protein, human
SOCS3 protein, human
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins
Transcription Factors