Abstract
Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Breast Neoplasms / metabolism
-
Breast Neoplasms / pathology*
-
Cell Division / drug effects
-
Colonic Neoplasms / metabolism
-
Colonic Neoplasms / pathology*
-
Female
-
Humans
-
Macrolides
-
Molecular Structure
-
Structure-Activity Relationship
-
Taxoids / chemical synthesis*
-
Taxoids / chemistry
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Macrolides
-
Taxoids
-
laulimalide