Abstract
Proteins can be localized either by inclusion or exclusion, and the Par polarity proteins illustrate both mechanisms. Cdc42 recruits Par-6 to a limited region of the plasma membrane. Par-6 recruits Par-3, which is actively removed from other regions by Par-1 and Par-5. Inclusion and exclusion together ensure efficient segregation of the polarity proteins.
MeSH terms
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14-3-3 Proteins
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Animals
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Caenorhabditis elegans Proteins / metabolism
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Cell Polarity / genetics*
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Models, Biological*
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Phosphorylation
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Protein Kinase C / metabolism
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Protein Serine-Threonine Kinases
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Proteins / metabolism*
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Signal Transduction*
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Tyrosine 3-Monooxygenase / metabolism
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cdc42 GTP-Binding Protein / metabolism*
Substances
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14-3-3 Proteins
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Caenorhabditis elegans Proteins
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Proteins
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par-5 protein, C elegans
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par-6 protein, C elegans
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Tyrosine 3-Monooxygenase
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PAR-3 protein, C elegans
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Protein Serine-Threonine Kinases
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PKC-3 protein
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Protein Kinase C
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cdc42 GTP-Binding Protein