Abstract
Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.
MeSH terms
-
Amino Acid Motifs
-
Amino Acid Sequence
-
Crystallography, X-Ray
-
Estrogen Receptor alpha
-
Leucine / chemistry
-
Ligands
-
Molecular Conformation
-
Molecular Sequence Data
-
Oligopeptides / chemistry
-
Oligopeptides / metabolism
-
Receptors, Cytoplasmic and Nuclear / agonists
-
Receptors, Cytoplasmic and Nuclear / chemistry*
-
Receptors, Cytoplasmic and Nuclear / metabolism
-
Receptors, Estrogen / agonists
-
Receptors, Estrogen / chemistry
-
Receptors, Estrogen / metabolism
-
Sequence Alignment
-
Transcription Factors / chemistry*
-
Transcription Factors / metabolism
Substances
-
Estrogen Receptor alpha
-
Ligands
-
Oligopeptides
-
Receptors, Cytoplasmic and Nuclear
-
Receptors, Estrogen
-
Transcription Factors
-
Leucine