Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils

Gene. 1992 Sep 10;118(2):303-4. doi: 10.1016/0378-1119(92)90208-7.

Abstract

We cloned a cDNA (RFP) encoding a receptor (RFP) related (70% overall nucleotide homology) to the formyl peptide receptor of human neutrophils (hFPR). RFP is a seven-transmembrane-domain receptor and its distribution is limited to myeloid cells. Domain sequence comparison with hFPR reveals highly conserved regions and provides clues to putative domains involved in ligand binding and receptor desensitization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Line
  • Cloning, Molecular
  • DNA / genetics
  • Humans
  • Molecular Sequence Data
  • N-Formylmethionine Leucyl-Phenylalanine / metabolism*
  • Neutrophils / metabolism*
  • Receptors, Formyl Peptide
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / metabolism
  • Sequence Homology, Nucleic Acid

Substances

  • Receptors, Formyl Peptide
  • Receptors, Immunologic
  • N-Formylmethionine Leucyl-Phenylalanine
  • DNA

Associated data

  • GENBANK/X63819