IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

J Clin Invest. 2004 May;113(9):1271-6. doi: 10.1172/JCI20945.

Abstract

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL-6-hepcidin axis is responsible for the hypoferremia of inflammation.

Publication types

  • Comparative Study

MeSH terms

  • Anemia / etiology*
  • Animals
  • Antimicrobial Cationic Peptides / biosynthesis*
  • Antimicrobial Cationic Peptides / urine
  • Cell Line
  • Cells, Cultured
  • Gene Expression Regulation
  • Hepatocytes / cytology
  • Hepcidins
  • Humans
  • Inflammation / complications
  • Inflammation / metabolism*
  • Interleukin-6 / blood
  • Interleukin-6 / metabolism*
  • Iron / metabolism
  • Iron Metabolism Disorders / pathology
  • Kupffer Cells / cytology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Monocytes / cytology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Antimicrobial Cationic Peptides
  • HAMP protein, human
  • Hamp protein, mouse
  • Hepcidins
  • Interleukin-6
  • RNA, Messenger
  • Iron