Abstract
3-Alkyl- and 3-aryl-7H-furo[3,2-g]chromen-7-ones were synthesised and studied for their effects on voltage-gated K+ and Na+ channels of the neuroblastoma cell-line N1E-115 and K+ channels of L-929 mouse-fibroblasts, stably transfected with mKv1.3. All furocoumarins tested showed Kv channel blocking activities, the most potent one in a half-blocking concentration of 0.7 microM.
MeSH terms
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Animals
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Brain Neoplasms / metabolism
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Cell Line, Tumor
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Cells, Cultured
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Coumarins / chemical synthesis*
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Coumarins / pharmacology*
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Fibroblasts
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Humans
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Ion Channel Gating / drug effects
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Kv1.3 Potassium Channel
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Membrane Potentials / drug effects
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Mice
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Neuroblastoma / metabolism
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Patch-Clamp Techniques
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Potassium Channel Blockers / chemical synthesis*
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Potassium Channel Blockers / pharmacology*
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Potassium Channels / drug effects*
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Potassium Channels, Voltage-Gated*
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Sodium Channel Blockers / chemical synthesis
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Sodium Channel Blockers / pharmacology
Substances
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Coumarins
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KCNA3 protein, human
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Kcna3 protein, mouse
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Kv1.3 Potassium Channel
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Potassium Channel Blockers
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Potassium Channels
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Potassium Channels, Voltage-Gated
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Sodium Channel Blockers