Abstract
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the alpha7 nicotinic acetylcholine (alpha7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the alpha7 receptor.
MeSH terms
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Animals
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Aza Compounds / chemistry
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Binding Sites
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Bridged Bicyclo Compounds / chemistry
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Dose-Response Relationship, Drug
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Models, Chemical
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Nicotinic Agonists / chemical synthesis*
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Nicotinic Agonists / pharmacokinetics
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Octanes / chemical synthesis*
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Octanes / pharmacokinetics
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PC12 Cells / drug effects
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Rats
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Receptors, Nicotinic / drug effects
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Receptors, Nicotinic / metabolism*
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Thiophenes / chemistry
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alpha7 Nicotinic Acetylcholine Receptor
Substances
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Aza Compounds
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Bridged Bicyclo Compounds
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Chrna7 protein, rat
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Nicotinic Agonists
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Octanes
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Receptors, Nicotinic
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Thiophenes
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alpha7 Nicotinic Acetylcholine Receptor