DNA damage-induced activation of ATM and ATM-dependent signaling pathways

Ebba U Kurz; Susan P Lees-Miller

doi:10.1016/j.dnarep.2004.03.029

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):889-900. doi: 10.1016/j.dnarep.2004.03.029.

Authors

Ebba U Kurz¹, Susan P Lees-Miller

Affiliation

¹ Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada.

PMID: 15279774
DOI: 10.1016/j.dnarep.2004.03.029

Abstract

Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell cycle checkpoints. In this review, we describe recent developments in our understanding of the mechanism of activation of ATM and its downstream signaling pathways, and explore whether DNA double-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Ataxia Telangiectasia Mutated Proteins
Cell Cycle
Cell Cycle Proteins
DNA Damage*
DNA-Binding Proteins
Humans
Models, Biological
Phosphorylation
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / physiology*
Protein Structure, Tertiary
Radiation, Ionizing
Signal Transduction
Tumor Suppressor Protein p53 / physiology
Tumor Suppressor Proteins

Substances

Cell Cycle Proteins
DNA-Binding Proteins
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
ATM protein, human
Ataxia Telangiectasia Mutated Proteins
Protein Serine-Threonine Kinases