Abstract
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
MeSH terms
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Animals
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Cell Division / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Ethers, Cyclic / chemical synthesis
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Ethers, Cyclic / chemistry*
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Ethers, Cyclic / pharmacology*
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Furans / chemical synthesis
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Furans / chemistry
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Furans / pharmacology
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Humans
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Ketones / chemical synthesis
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Ketones / chemistry*
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Ketones / pharmacology*
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Macrocyclic Compounds / chemical synthesis
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Macrocyclic Compounds / chemistry*
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Macrocyclic Compounds / pharmacology*
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Macrolides
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Mice
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Molecular Conformation
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Structure-Activity Relationship
Substances
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Ethers, Cyclic
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Furans
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Ketones
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Macrocyclic Compounds
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Macrolides
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halichondrin B
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eribulin