Dimerization of alpha1-adrenoceptors

G Milligan; J Pediani; M Fidock; J F López-Giménez

doi:10.1042/BST0320847

Dimerization of alpha1-adrenoceptors

Biochem Soc Trans. 2004 Nov;32(Pt 5):847-50. doi: 10.1042/BST0320847.

Authors

G Milligan¹, J Pediani, M Fidock, J F López-Giménez

Affiliation

¹ Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. g.milligan@bio.gla.ac.uk

PMID: 15494031
DOI: 10.1042/BST0320847

Abstract

Three distinct genes encode alpha(1)-adrenoceptors. Although homodimers of each subtype have been reported, certain but not all combinations of heterodimers of the alpha(1)-adrenoceptors appear to form. Key studies in this field are reviewed and the approaches that have been applied to monitoring the selectivity and the basis of alpha(1)-adrenoceptor dimerization are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA / chemistry
DNA, Complementary / metabolism
Dimerization
Humans
Ligands
Protein Binding
Protein Structure, Quaternary
Receptors, Adrenergic, alpha-1 / chemistry*
Receptors, G-Protein-Coupled / chemistry*
Structure-Activity Relationship

Substances

DNA, Complementary
Ligands
Receptors, Adrenergic, alpha-1
Receptors, G-Protein-Coupled
DNA