Abstract
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.
MeSH terms
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ATP-Binding Cassette Transporters / agonists
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ATP-Binding Cassette Transporters / metabolism*
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Adenosine Triphosphate / metabolism
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Animals
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Benzamides / chemistry*
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Benzamides / pharmacology*
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Benzothiadiazines / chemistry
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Benzothiadiazines / pharmacology
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Diazoxide / analogs & derivatives*
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Diazoxide / chemistry
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Diazoxide / pharmacology
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism
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Potassium Channels / agonists
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Potassium Channels / metabolism*
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Potassium Channels, Inwardly Rectifying / agonists
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Potassium Channels, Inwardly Rectifying / metabolism*
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Pyridines / chemistry
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Pyridines / pharmacology
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Rats
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Receptors, Drug / agonists
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Receptors, Drug / metabolism*
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Sulfonylurea Receptors
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Thiadiazines / chemistry
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Thiadiazines / pharmacology
Substances
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7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
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ATP-Binding Cassette Transporters
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Abcc8 protein, rat
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BPDZ 62
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Benzamides
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Benzothiadiazines
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Kir6.2 channel
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Pyridines
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Receptors, Drug
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Sulfonylurea Receptors
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Thiadiazines
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Adenosine Triphosphate
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Diazoxide