Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

An De Naeyer; Wim Vanden Berghe; Victoria Pocock; Stuart Milligan; Guy Haegeman; Denis De Keukeleire

doi:10.1021/np040069a

Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

J Nat Prod. 2004 Nov;67(11):1829-32. doi: 10.1021/np040069a.

Authors

An De Naeyer¹, Wim Vanden Berghe, Victoria Pocock, Stuart Milligan, Guy Haegeman, Denis De Keukeleire

Affiliation

¹ Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

PMID: 15568770
DOI: 10.1021/np040069a

Abstract

Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Belgium
Breast Neoplasms
Drug Screening Assays, Antitumor
Estrogens / chemistry
Estrogens / isolation & purification
Estrogens / pharmacology*
Female
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Humans
Inhibitory Concentration 50
Molecular Structure
Phytotherapy*
Plants, Medicinal / chemistry*
Sophora / chemistry*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Estrogens
Flavonoids
kurarinone