Abstract
Head and neck squamous cell carcinomas exhibit alterations in cell proliferation, survival (apoptosis), migration, angiogenesis and inflammation. The transcription factor nuclear factor-KappaB integrates multiple signals and regulates expression of multiple genes involved in these phenotypic responses, suggesting the hypothesis that nuclear factor-KappaB is an important molecular switch for development of head and neck squamous cell carcinoma. Nuclear factor-KappaB has been found to be constitutively activated, and a common target and activator of oncogenes in cancer. Because of its important role, activation of nuclear factor-KappaB by the proteasome and other signal molecules may provide targets for molecular therapy of squamous cell carcinoma and other cancers.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis*
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / genetics*
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Carcinoma, Squamous Cell / mortality
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Clinical Trials as Topic
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Disease Models, Animal
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Disease Progression
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Female
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Gene Expression Regulation, Neoplastic
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Head and Neck Neoplasms / drug therapy
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Head and Neck Neoplasms / genetics*
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Head and Neck Neoplasms / mortality
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Humans
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Male
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Mice
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NF-kappa B / genetics
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NF-kappa B / metabolism*
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Neoplasm Staging
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Oncogenes / drug effects
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Oncogenes / genetics
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Prognosis
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Risk Factors
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Sensitivity and Specificity
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Survival Analysis
Substances
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Biomarkers, Tumor
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NF-kappa B