Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

Topi Tervonen; Karl Akerman; Ben A Oostra; Maija Castrén

doi:10.1016/j.molbrainres.2004.09.023

Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

Brain Res Mol Brain Res. 2005 Jan 5;133(1):162-5. doi: 10.1016/j.molbrainres.2004.09.023.

Authors

Topi Tervonen¹, Karl Akerman, Ben A Oostra, Maija Castrén

Affiliation

¹ Neuroscience Center, University of Helsinki, P.O. Box 56, Viikinkaari 4, FIN-00014 Helsinki, Finland.

PMID: 15661377
DOI: 10.1016/j.molbrainres.2004.09.023

Abstract

In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Brain / growth & development
Brain / metabolism*
Fragile X Mental Retardation Protein
Gene Expression / physiology*
In Situ Hybridization / methods
Mice
Mice, Knockout
Nerve Tissue Proteins / deficiency*
Nerve Tissue Proteins / genetics
RGS Proteins / genetics
RGS Proteins / metabolism*
RNA, Messenger / metabolism
RNA-Binding Proteins / genetics

Substances

Fmr1 protein, mouse
Nerve Tissue Proteins
RGS Proteins
RNA, Messenger
RNA-Binding Proteins
Fragile X Mental Retardation Protein
RGS4 protein