The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS

Prog Med Chem. 2005:43:239-71. doi: 10.1016/S0079-6468(05)43007-6.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / metabolism
  • CCR5 Receptor Antagonists*
  • Chemokine CCL4
  • Cyclohexanes / chemistry
  • Cyclohexanes / isolation & purification*
  • Cyclohexanes / metabolism
  • Humans
  • Macrophage Inflammatory Proteins / metabolism
  • Maraviroc
  • Protein Binding
  • Radioligand Assay
  • Receptors, CCR5 / chemistry
  • Receptors, HIV / drug effects
  • Triazoles / chemistry
  • Triazoles / isolation & purification*
  • Triazoles / metabolism

Substances

  • Anti-HIV Agents
  • CCR5 Receptor Antagonists
  • Chemokine CCL4
  • Cyclohexanes
  • Macrophage Inflammatory Proteins
  • Receptors, CCR5
  • Receptors, HIV
  • Triazoles
  • Maraviroc