Abstract
Human African trypanosomiasis is a lethal parasitic infection with neurological involvement. Examination of the cerebrospinal fluid (CSF) plays an essential role in diagnosis, selection of treatment and post-treatment follow-up. This paper reviews clinical presentation, diagnosis and treatment of the disease, with emphasis on CSF characteristics and interpretation of the CSF results for therapeutic decision and post-treatment follow-up.
MeSH terms
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Animals
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Central Nervous System Infections / cerebrospinal fluid
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Central Nervous System Infections / diagnosis
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Central Nervous System Infections / drug therapy
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Decision Making
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Humans
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Immunoglobulins / analysis
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Trypanosoma brucei gambiense / isolation & purification
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Trypanosoma brucei rhodesiense / isolation & purification
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Trypanosomiasis, African / cerebrospinal fluid*
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Trypanosomiasis, African / diagnosis
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Trypanosomiasis, African / drug therapy