Abstract
Increasing evidence indicates that the tight junction plays a role in membrane transport. Various signalling and trafficking molecules localize to the sites of cell-cell junctions in epithelial cells, including Rab proteins, a family of small GTPases that regulate different steps of vesicular transport along the endocytic and exocytic pathways. We have recently shown that Rab13 controls protein kinase A activity, demonstrating a clear biochemical and functional link between Rab13 and protein kinase A signalling during tight junction assembly in epithelial cells. The present article focuses on how protein kinase A signalling and protein trafficking events could be integrated at tight junctions in epithelial cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Transport
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Cell Adhesion Molecules / metabolism
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Cell Membrane / metabolism*
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Cell Polarity
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Epithelial Cells / metabolism
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Membrane Proteins / metabolism
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Microfilament Proteins
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Models, Biological
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Phosphoproteins / metabolism
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Protein Transport*
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SNARE Proteins
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Signal Transduction*
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Tight Junctions / metabolism*
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Vesicular Transport Proteins / metabolism
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rab GTP-Binding Proteins / metabolism
Substances
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Cell Adhesion Molecules
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Membrane Proteins
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Microfilament Proteins
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Phosphoproteins
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SNARE Proteins
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Vesicular Transport Proteins
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vasodilator-stimulated phosphoprotein
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Cyclic AMP-Dependent Protein Kinases
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rab GTP-Binding Proteins