Transcriptional regulation and transformation by Myc proteins

Sovana Adhikary; Martin Eilers

doi:10.1038/nrm1703

Transcriptional regulation and transformation by Myc proteins

Nat Rev Mol Cell Biol. 2005 Aug;6(8):635-45. doi: 10.1038/nrm1703.

Authors

Sovana Adhikary¹, Martin Eilers

Affiliation

¹ Institute for Molecular Biology and Tumour Research, University of Marburg, Emil-Mannkopff-Strasse 2, 35033 Marburg, Germany.

PMID: 16064138
DOI: 10.1038/nrm1703

Abstract

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the genesis of most human tumours. Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Binding Sites
Cell Transformation, Neoplastic / genetics*
DNA-Binding Proteins / metabolism
Gene Expression Regulation, Neoplastic*
Humans
Proto-Oncogene Proteins c-myc / metabolism*
Repressor Proteins / metabolism
Transcription, Genetic

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins c-myc
Repressor Proteins