Abstract
At least two different types of sigma (sigma1 and sigma2) receptors have been identified. A structural feature common to high-affinity (Ki <10 nM) sigma1 ligands is: C-N(R)-X-Ph; both C and Ph are associated with regions of bulk tolerance. Numerous other ligands bind, but typically do so with lower affinity.
MeSH terms
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Amines / chemical synthesis
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Amines / pharmacology*
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Animals
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Humans
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Ligands
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Piperazines / chemical synthesis
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Piperazines / pharmacology*
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Piperidines / chemical synthesis
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Piperidines / pharmacology*
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Protein Binding
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Receptors, Drug / metabolism*
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Receptors, sigma / metabolism*
Substances
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Amines
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Ligands
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Piperazines
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Piperidines
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Receptors, Drug
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Receptors, sigma