Abstract
Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .
MeSH terms
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Animals
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Enzyme Activation
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Enzyme Inhibitors / pharmacology*
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HSP90 Heat-Shock Proteins / drug effects*
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Humans
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JNK Mitogen-Activated Protein Kinases / metabolism
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Neurodegenerative Diseases / enzymology
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Neurodegenerative Diseases / prevention & control*
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Neuroprotective Agents / pharmacology*
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Signal Transduction
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Sulfonamides / pharmacology*
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Thiadiazoles / pharmacology*
Substances
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AEG 3482
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Enzyme Inhibitors
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HSP90 Heat-Shock Proteins
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Neuroprotective Agents
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Sulfonamides
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Thiadiazoles
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JNK Mitogen-Activated Protein Kinases