Targeting HSP90 to halt neurodegeneration

Chem Biol. 2006 Feb;13(2):115-6. doi: 10.1016/j.chembiol.2006.02.003.

Abstract

Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .

Publication types

  • Comment

MeSH terms

  • Animals
  • Enzyme Activation
  • Enzyme Inhibitors / pharmacology*
  • HSP90 Heat-Shock Proteins / drug effects*
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Neurodegenerative Diseases / enzymology
  • Neurodegenerative Diseases / prevention & control*
  • Neuroprotective Agents / pharmacology*
  • Signal Transduction
  • Sulfonamides / pharmacology*
  • Thiadiazoles / pharmacology*

Substances

  • AEG 3482
  • Enzyme Inhibitors
  • HSP90 Heat-Shock Proteins
  • Neuroprotective Agents
  • Sulfonamides
  • Thiadiazoles
  • JNK Mitogen-Activated Protein Kinases