KATP channels as molecular sensors of cellular metabolism

Nature. 2006 Mar 23;440(7083):470-6. doi: 10.1038/nature04711.

Abstract

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K(ATP)) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.

Publication types

  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Cells / metabolism*
  • Crystallography, X-Ray
  • Diabetes Mellitus / metabolism
  • Forecasting
  • Humans
  • Hyperinsulinism / metabolism
  • Ion Channel Gating
  • Mutation
  • Potassium Channels / chemistry
  • Potassium Channels / genetics
  • Potassium Channels / metabolism*
  • Potassium Channels, Inwardly Rectifying / metabolism
  • Protein Conformation
  • Receptors, Drug / metabolism
  • Sulfonylurea Receptors

Substances

  • ATP-Binding Cassette Transporters
  • Potassium Channels
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Drug
  • Sulfonylurea Receptors
  • Adenosine Triphosphate