Abstract
[reaction: see text] A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / economics
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Antineoplastic Agents* / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Macrolides
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Molecular Structure
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Paclitaxel / pharmacology
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Structure-Activity Relationship
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Taxoids* / chemical synthesis
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Taxoids* / chemistry
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Taxoids* / economics
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Taxoids* / pharmacology
Substances
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11-desmethyllaulimalide
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Antineoplastic Agents
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Macrolides
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Taxoids
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laulimalide
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Paclitaxel