Histone lysine demethylases and their impact on epigenetics

Patrick Trojer; Danny Reinberg

doi:10.1016/j.cell.2006.04.003

Histone lysine demethylases and their impact on epigenetics

Cell. 2006 Apr 21;125(2):213-7. doi: 10.1016/j.cell.2006.04.003.

Authors

Patrick Trojer¹, Danny Reinberg

Affiliation

¹ Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

PMID: 16630806
DOI: 10.1016/j.cell.2006.04.003

Abstract

Methylation marks on the lysine residues of histone proteins are thought to contribute to epigenetic phenomena in part because of their apparent irreversibility. Will this view change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?

MeSH terms

Animals
Chromatin / metabolism
Epigenesis, Genetic*
Histones / metabolism*
Lysine / metabolism*
Methylation
Oxidoreductases, N-Demethylating / metabolism*

Substances

Chromatin
Histones
Oxidoreductases, N-Demethylating
Lysine