Abstract
Regulators of G protein signaling (RGS proteins) bind directly to activated Galpha subunits to inhibit their signaling. However, recent findings show that RGS proteins selectively regulate signaling by certain G protein-coupled receptors (GPCRs) in cells, irrespective of the coupled G protein. New studies support an emerging model that suggests RGS proteins utilize both direct and indirect mechanisms to form stable functional pairs with preferred GPCRs to selectively modulate the signaling functions of those receptors and linked G proteins. Here, we discuss these findings and their implications for established models of GPCR signaling.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Cell Physiological Phenomena
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Forecasting
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GTP-Binding Protein Regulators / genetics
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GTP-Binding Protein Regulators / metabolism
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GTP-Binding Protein Regulators / physiology*
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GTP-Binding Proteins / genetics
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GTP-Binding Proteins / metabolism
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GTP-Binding Proteins / physiology*
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Humans
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Models, Biological
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RGS Proteins / chemistry
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RGS Proteins / genetics
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RGS Proteins / metabolism
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RGS Proteins / physiology*
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Receptors, G-Protein-Coupled / metabolism
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Receptors, G-Protein-Coupled / physiology*
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Signal Transduction / physiology*
Substances
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GTP-Binding Protein Regulators
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RGS Proteins
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Receptors, G-Protein-Coupled
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GTP-Binding Proteins