Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

Mathieu Sassatelli; Eric Debiton; Bettina Aboab; Michelle Prudhomme; Pascale Moreau

doi:10.1016/j.ejmech.2006.03.021

Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties

Eur J Med Chem. 2006 Jun;41(6):709-16. doi: 10.1016/j.ejmech.2006.03.021. Epub 2006 May 3.

Authors

Mathieu Sassatelli¹, Eric Debiton, Bettina Aboab, Michelle Prudhomme, Pascale Moreau

Affiliation

¹ Laboratoire SEESIB, Université Blaise-Pascal, UMR 6504 du CNRS, 24 avenue des Landais, 63177 Aubière, France.

PMID: 16675065
DOI: 10.1016/j.ejmech.2006.03.021

Abstract

A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).

MeSH terms

Amino Acids / chemistry*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Indoles / chemical synthesis*
Indoles / chemistry
Indoles / pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Spectrophotometry, Infrared

Substances

Amino Acids
Antineoplastic Agents
Indoles