The development of our knowledge on the structure, molecular regulation, and cell function on transient receptor potential (TRP) channels has been growing dramatically during the last few years. Many meetings in the past and upcoming events are now focused on TRP channels as general sensor molecules in cell physiology. However, most of the scientists in the field still feel that we are just beginning to understand these truly remarkable proteins, called TRPs, and there is still a long way to go from structure via molecular regulation to cell and organ function. This generally accepted but exciting view about the long road to the understanding of TRPs dominated all presentations given at the 2006 Minerva-Gentner Symposium on TRP channels and calcium signalling, which was held in Eilat, Israel, and was excellently organized by Baruch Minke (Jerusalem, Israel) and supported by Veit Flockerzi (Homburg, Germany).