Abstract
It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).
MeSH terms
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Animals
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Immune Tolerance / genetics
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Immune Tolerance / immunology*
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Inflammation / chemically induced
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Inflammation / genetics
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Inflammation / immunology*
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Inflammation Mediators / immunology
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Inflammation Mediators / metabolism
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Intestine, Small / drug effects
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Intestine, Small / immunology*
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Intestine, Small / physiopathology
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Male
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NF-kappa B / metabolism*
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Pregnane X Receptor
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Receptors, Steroid / metabolism*
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Repressor Proteins / immunology
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Repressor Proteins / metabolism
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Signal Transduction / immunology
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Transcriptional Activation / genetics
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Transcriptional Activation / immunology
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Xenobiotics / adverse effects
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Xenobiotics / immunology
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Xenobiotics / metabolism*
Substances
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Inflammation Mediators
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NF-kappa B
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Pregnane X Receptor
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Receptors, Steroid
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Repressor Proteins
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Xenobiotics