Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration

N Engl J Med. 2006 Sep 14;355(11):1088-91. doi: 10.1056/NEJMp068159.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoantigens
  • Cell Movement / drug effects
  • Central Nervous System / immunology
  • Down-Regulation
  • Fingolimod Hydrochloride
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*
  • Lymph Nodes / immunology
  • Lysophospholipids / agonists
  • Lysophospholipids / metabolism
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Propylene Glycols / adverse effects
  • Propylene Glycols / pharmacology
  • Propylene Glycols / therapeutic use*
  • Sphingosine / adverse effects
  • Sphingosine / agonists
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • Sphingosine / pharmacology
  • Sphingosine / therapeutic use
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / physiology

Substances

  • Autoantigens
  • Immunosuppressive Agents
  • Lysophospholipids
  • Propylene Glycols
  • sphingosine 1-phosphate
  • Fingolimod Hydrochloride
  • Sphingosine