Abstract
We investigated the effect of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl), a marker compound isolated from the cortex of Magnolia officinalis, in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with magnolol (100 mg/kg body weight) once a day for 13 weeks. In magnolol-treated GK rats, fasting blood glucose and plasma insulin were significantly decreased, and the pancreatic islets also showed strong insulin antigen positivity. Urinary protein and creatinine clearance (Ccr) were significantly decreased. Pathological examination revealed the prevention of the glomeruli enlargement in magnolol-treated GK rats. The overproduction of renal sorbitol, advanced glycation endproducts (AGEs), type IV collagen, and TGF-beta1 mRNA were significantly reduced in magnolol-treated GK rats. Thus based on our findings, the use of magnolol could result in good blood glucose control and prevent or retard development of diabetic complications such as diabetic nephropathy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biphenyl Compounds / administration & dosage
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / therapeutic use*
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Blood Glucose / metabolism
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Collagen Type IV / metabolism
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Creatinine / analysis
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Experimental / metabolism
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / metabolism
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Diabetic Nephropathies / drug therapy*
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Diabetic Nephropathies / metabolism
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Glycation End Products, Advanced / metabolism
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / therapeutic use*
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Immunohistochemistry
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Insulin / metabolism
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism
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Kidney Cortex / drug effects
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Kidney Cortex / metabolism
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Lignans / administration & dosage
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Lignans / isolation & purification
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Lignans / therapeutic use*
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Magnolia / chemistry
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Male
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Plant Bark / chemistry
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Plant Roots / chemistry
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Proteinuria / prevention & control
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Rats
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Rats, Inbred Strains
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Sorbitol / metabolism
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Transforming Growth Factor beta1 / metabolism
Substances
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Biphenyl Compounds
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Blood Glucose
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Collagen Type IV
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Glycation End Products, Advanced
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Hypoglycemic Agents
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Insulin
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Lignans
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Transforming Growth Factor beta1
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magnolol
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Sorbitol
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Creatinine