Lipoprotein-associated phospholipase A(2) : review of its role as a marker and a potential participant in coronary endothelial dysfunction

Mol Diagn Ther. 2007;11(4):219-26. doi: 10.1007/BF03256243.

Abstract

The role of inflammation in atherosclerosis continues to emerge. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a novel plasma biomarker, circulates in the blood bound mainly to low-density lipoprotein (LDL) and promotes vascular inflammation. Several epidemiological studies have shown that circulating levels of Lp-PLA(2) are an independent risk factor for cardiovascular events. Recent studies demonstrate that Lp-PLA(2) is also associated with endothelial dysfunction and early atherosclerosis. This review provides an overview of these studies, suggests plausible mechanisms for the association between endothelial dysfunction and Lp-PLA(2), and highlights future potential therapies.

Publication types

  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / analysis
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism*
  • Animals
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Coronary Disease / enzymology*
  • Coronary Disease / physiopathology*
  • Coronary Disease / therapy
  • Endothelium, Vascular / enzymology*
  • Endothelium, Vascular / physiopathology*
  • Humans
  • Inflammation

Substances

  • Biomarkers
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase