Abstract
This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration. More specifically, C-terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer's, Parkinson's and motor neuron disease.
MeSH terms
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Acetylcholinesterase / chemistry
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Acetylcholinesterase / metabolism*
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Alzheimer Disease / enzymology
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Alzheimer Disease / pathology
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Animals
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Humans
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Models, Biological
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Motor Neuron Disease / enzymology
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Motor Neuron Disease / pathology
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Nerve Degeneration / enzymology
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Nerve Degeneration / pathology
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Parkinson Disease / enzymology
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Parkinson Disease / pathology
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Peptides / chemistry
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Peptides / physiology*
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Signal Transduction / physiology*
Substances
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Peptides
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Acetylcholinesterase