Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues

ChemMedChem. 2008 Jul;3(7):1027-9. doi: 10.1002/cmdc.200800037.

Authors

Klemens Högenauer¹, Andreas Billich, Charles Pally, Markus Streiff, Trixie Wagner, Karl Welzenbach, Peter Nussbaumer

Affiliation

¹ Novartis Institutes for Biomedical Research, Brunner Strasse 59, 1235 Wien, Austria. klemens.hoegenauer@novartis.com

PMID: 18383466
DOI: 10.1002/cmdc.200800037

No abstract available

MeSH terms

Catalysis
Fingolimod Hydrochloride
Immunosuppressive Agents / chemistry
Immunosuppressive Agents / pharmacology*
Models, Chemical
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor) / chemistry
Phosphotransferases (Alcohol Group Acceptor) / metabolism*
Propylene Glycols / chemistry
Propylene Glycols / pharmacology*
Sphingosine / analogs & derivatives*
Sphingosine / chemistry
Sphingosine / pharmacology

Substances

Immunosuppressive Agents
Propylene Glycols
Phosphotransferases (Alcohol Group Acceptor)
sphingosine kinase
Fingolimod Hydrochloride
Sphingosine