One-pot approach for the synthesis of trans-cyclopropyl compounds from aldehydes. Application to the synthesis of GPR40 receptor agonists

Chem Commun (Camb). 2008 Oct 28:(40):4974-6. doi: 10.1039/b810708d. Epub 2008 Sep 12.

Abstract

A novel multicatalytic one-pot process providing trans-cyclopropyl compounds from corresponding aldehydes has been developed and applied to the synthesis of GPR40 small molecule agonists.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkenes / chemistry
  • Catalysis
  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry
  • Receptors, G-Protein-Coupled / agonists*
  • Stereoisomerism

Substances

  • Aldehydes
  • Alkenes
  • Cyclopropanes
  • Receptors, G-Protein-Coupled
  • cyclopropane