A gut feeling for obesity: 7TM sensors on enteroendocrine cells

Cell Metab. 2008 Dec;8(6):447-9. doi: 10.1016/j.cmet.2008.11.004.

Abstract

Enteroendocrine cells, which secrete peptide hormones in response to sensation of food and gut microbiota products, can now be genetically tagged, isolated, cultured, and characterized for expression of the elusive chemosensors, as shown in publications in PNAS (Samuel et al., 2008) and in this issue (Reimann et al., 2008).

Publication types

  • Comment

MeSH terms

  • Bile Acids and Salts / metabolism
  • Enteroendocrine Cells / metabolism
  • Enteroendocrine Cells / physiology*
  • Gastrointestinal Hormones / pharmacology
  • Glucagon-Like Peptide 1 / metabolism
  • Humans
  • Obesity / drug therapy
  • Receptors, Cell Surface / metabolism
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, G-Protein-Coupled / physiology*
  • Receptors, Lysophosphatidic Acid / metabolism

Substances

  • Bile Acids and Salts
  • FFA2R protein, human
  • FFAR1 protein, human
  • FFAR3 protein, human
  • FFAR4 protein, human
  • GPR119 protein, human
  • Gastrointestinal Hormones
  • LPAR5 protein, human
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Glucagon-Like Peptide 1