Abstract
Triple duty: A synthetic molecular clip traps nicotinamide adenine dinucleotide phosphate (NADP(+); see picture) as well as occupying both the cofactor- and the substrate-binding site in glucose-6-phosphate (G6P) dehydrogenase. This combination of two inhibition mechanisms makes the clip highly effective and selective for this enzyme over other dehydrogenases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Computer Simulation
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Crystallography, X-Ray
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Dehydroepiandrosterone / chemistry*
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Enzyme Inhibitors / chemistry*
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Glucosephosphate Dehydrogenase / antagonists & inhibitors*
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Glucosephosphate Dehydrogenase / metabolism
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Humans
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Kinetics
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NADP / metabolism*
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Protein Conformation
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Substrate Specificity
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Thermodynamics
Substances
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Enzyme Inhibitors
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Dehydroepiandrosterone
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NADP
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Glucosephosphate Dehydrogenase